5. 2012 Toyota Prius: 51/48 MPG
The best selling hybrid in the world, it’s responsible for half of all hybrid sales in the U.S. and ranks fifth on the EPA’s list of the Top 10 Most Fuel Efficient Cars.With a 51 mpg city and 48 mpg highway rating it was the first car to hit the magical 50 mpg average mark. Perhaps more impressive is that it even after several years on the market it’s still a leader. For 2012 the Prius gains Toyota’s Entune telematics system with numerous apps, including XM Fuel Prices to help you find the cheapest gas near you.