3. (Tie) Ford F-150 3.7 V6 2WD: 19 mpg
Appearing for a second time in our most fuel-friendly pickup trucks is the Ford F-150. When equipped with the 3.7L V6, you can get another mile per gallon compared to the EcoBoost version. The EPA numbers are 17 mpg in the city and 23 mpg on the highway. You will have to deal with lower power and torque numbers than the EcoBoost, at just 302 hp and 278lb-ft of torque. These are the sacrifices one has to make in order to get a combined 19 mpg.